NSIP in a curry sauce factory worker

was significantly less inHAPE-p than in HAPE-r (1% v 9%, odds ratio 0.10 (95% CI 0.01 to 0.82), p = 0.01). Our findings support the hypothesis that ACE and ET-1 polymorphisms have a role in the susceptibility to HAPE. The findings of the present study and earlier reports on adaptation to high altitude 3 together indicate that ACE and ET-1 genes are significant in high altitude physiology. In conclusion, this study showed that ACE and ET-1 variants have independent and interactive roles in the susceptibility to HAPE. Higher ACE activity and ET-1 levels correlated with HAPE. The ACE I/D and ET-1 G2288T polymorphisms emerged as noteworthy variants showing association with HAPE. Owing to the small sample size, the difference in representation of the polymorphisms and their correlation with biochemical parameters did not reach greater statistical significance; in particular, we consider our data on the genotype combinations between the polymorphisms of the two genes to be preliminary. Nevertheless, since HAPE samples are difficult to obtain, the findingsof this study are important and warrant confirmation in a larger sample. The results of this study may find application in identifying individuals with a predisposition to HAPE.